Selected Publications

Kidney Disease

  1. Ceccotti E, Chiabotto G, Cedrino M, Gambella A, Delsedime L, Ghigo A, Salio C, Grange C, Herrera Sanchez MB, Femminò S, Sassoè-Pognetto M, Brizzi MF, Camussi G, Bruno S. Extracellular Vesicles Derived from Human Liver Stem Cells Counteract Chronic Kidney Disease Development and Cardiac Dysfunction in Remnant Kidney Murine Model: The Possible Involvement of Proteases. Biomedicines. 2024 Jul 8;12(7):1517. doi: 10.3390/biomedicines12071517. PMID: 39062090; PMCID: PMC11274379.

  2. Kholia S, Herrera Sanchez MB, Deregibus MC, Sassoè-Pognetto M, Camussi G, Brizzi MF. Human Liver Stem Cell Derived Extracellular Vesicles Alleviate Kidney Fibrosis by Interfering with the β-Catenin Pathway through miR29b. Int J Mol Sci. 2021 Oct 5;22(19):10780.

  3. Kholia S, Herrera Sanchez MB, Cedrino M, Papadimitriou E, Tapparo M, Deregibus MC, Bruno S, Antico F, Brizzi MF, Quesenberry PJ, Camussi G. Mesenchymal Stem Cell Derived Extracellular Vesicles Ameliorate Kidney Injury in Aristolochic Acid Nephropathy. Front Cell Dev Biol. 2020 Mar 24;8:188. doi: 10.3389/fcell.2020.00188. PMID: 32266268; PMCID: PMC7105599.

  4. Kholia S, Herrera Sanchez MB, Cedrino M, Papadimitrou E, Tapparo M, Deregibus MC, Brizzi MF, Tetta C, Camussi G. Human liver stem cell derived extracellular vesicles prevents aristolochic acid induced kidney fibrosis. Frontiers of immunology, 2018, DOI: 10.3389/fimmu.2018.01639.

  5. Herrera Sanchez MB, Bruno S, Grange C, Tapparo M, Cantaluppi V, Tetta C, Camussi G. Human liver stem cells and derived extracellular vesicles improve recovery in a murine model of acute kidney injury. Stem Cell Res Ther. 2014 Nov 10;5(6):124. doi: 10.1186/scrt514. PMID: 25384729; PMCID: PMC4446072.

  6. Arefin S, Mudrovcic N, Hobson S, Pietrocola F, Ebert T, Ward LJ, Witasp A, Hernandez L, Wennberg L, Lundgren T, Steinmetz-Späh J, Larsson K, Thorell A, Bruno S, Marengo M, Cantaluppi V, Stenvinkel P, Kublickiene K. Early vascular aging in chronic kidney disease: focus on microvascular maintenance, senescence signature and potential therapeutics. Transl Res. 2025 Jan;275:32-47. doi: 10.1016/j.trsl.2024.11.001. Epub 2024 Nov 5. Erratum in: Transl Res. 2025 Feb;276:38. doi: 10.1016/j.trsl.2024.12.003. PMID: 39510246.

  7. Herrera MB, Bussolati B, Bruno S, Morando L, Mauriello-Romanazzi G, Sanavio F, Stamenkovic I, Biancone L, Camussi G. Exogenous mesenchymal stem cells localize to the kidney by means of CD44 following acute tubular injury. Kidney Int. 2007 Aug;72(4):430-41. doi: 10.1038/sj.ki.5002334. Epub 2007 May 16. PMID: 17507906.

  8. Herrera MB, Bussolati B, Bruno S, Fonsato V, Romanazzi GM, Camussi G. Mesenchymal stem cells contribute to the renal repair of acute tubular epithelial injury. Int J Mol Med. 2004 Dec;14(6):1035-41. PMID: 15547670.

  9. Ceccotti E, Saccu G, Herrera Sanchez MB, Bruno S. Naïve or Engineered Extracellular Vesicles from Different Cell Sources: Therapeutic Tools for Kidney Diseases. Pharmaceutics. 2023 Jun 12;15(6):1715. doi: 10.3390/pharmaceutics15061715. PMID: 37376163; PMCID: PMC10303377.

Liver Disease

  1. Chiabotto G, Semnani A, Ceccotti E, Guenza M, Camussi G, Bruno S. Mesenchymal Stromal Cell-Derived Extracellular Vesicles for Reversing Hepatic Fibrosis in 3D Liver Spheroids. Biomedicines. 2024 Aug 14;12(8):1849. doi: 10.3390/biomedicines12081849. PMID: 39200313; PMCID: PMC11351945.

  2. Bruno S, Herrera Sanchez MB, Chiabotto G, Fonsato V, Navarro-Tableros V, Pasquino C, Tapparo M, Camussi G. Human Liver Stem Cells: A Liver-Derived Mesenchymal Stromal Cell-Like Population With Pro-regenerative Properties. Front Cell Dev Biol. 2021 Apr 26;9:644088. doi: 10.3389/fcell.2021.644088. PMID: 33981703; PMCID: PMC8107725.

  3. Bruno S, Pasquino C, Herrera Sanchez MB, Tapparo M, Figliolini F, Grange C, Chiabotto G, Cedrino M, Deregibus MC, Tetta C, Camussi G. HLSC-Derived Extracellular Vesicles Attenuate Liver Fibrosis and Inflammation in a Murine Model of Non-alcoholic Steatohepatitis. Mol Ther. 2020 Feb 5;28(2):479-489. doi: 10.1016/j.ymthe.2019.10.016. Epub 2019 Oct 28. PMID: 31757759; PMCID: PMC7001005.

  4. Famulari, E.S., Navarro-Tableros, V., Herrera Sanchez, M.B. et al. Human liver stem cells express UGT1A1 and improve phenotype of immunocompromised Crigler Najjar syndrome type I mice. Sci Rep 10, 887 (2020). https://doi.org/10.1038/s41598-020-57820-2.

  5. Bruno S, Herrera Sanchez MB, Pasquino C, Tapparo M, Cedrino M, Tetta C, Camussi G. Human Liver-Derived Stem Cells Improve Fibrosis and Inflammation Associated with Nonalcoholic Steatohepatitis. Stem Cells Int. 2019 Jun 2;2019:6351091. doi: 10.1155/2019/6351091. PMID: 31281379; PMCID: PMC6589210.

  6. Navarro-Tableros V, Herrera Sanchez MB, Figliolini F, Romagnoli R, Tetta C, Camussi G. Recellularization of rat liver scaffolds by human liver stem cells. Tissue Eng Part A. 2015 Jun;21(11-12):1929-39. doi: 10.1089/ten.TEA.2014.0573. Epub 2015 Apr 29. PMID: 25794768; PMCID: PMC4449720.

  7. Herrera MB, Fonsato V, Bruno S, Grange C, Gilbo N, Romagnoli R, Tetta C, Camussi G. Human liver stem cells improve liver injury in a model of fulminant liver failure. Hepatology. 2013 Jan;57(1):311-9. doi: 10.1002/hep.25986. PMID: 22829291.

  8. Fonsato V, Collino F, Herrera MB, Cavallari C, Deregibus MC, Cisterna B, Bruno S, Romagnoli R, Salizzoni M, Tetta C, Camussi G. Human liver stem cell-derived microvesicles inhibit hepatoma growth in SCID mice by delivering antitumor microRNAs. Stem Cells. 2012 Sep;30(9):1985-98. doi: 10.1002/stem.1161. PMID: 22736596; PMCID: PMC3468738.

  9. Herrera MB, Fonsato V, Gatti S, Deregibus MC, Sordi A, Cantarella D, Calogero R, Bussolati B, Tetta C, Camussi G. Human liver stem cell-derived microvesicles accelerate hepatic regeneration in hepatectomized rats. J Cell Mol Med. 2010 Jun;14(6B):1605-18. doi: 10.1111/j.1582-4934.2009.00860.x. Epub 2009 Jul 24. PMID: 19650833; PMCID: PMC3060338.

  10. Fonsato V, Herrera MB, Buttiglieri S, Gatti S, Camussi G, Tetta C. Use of a rotary bioartificial liver in the differentiation of human liver stem cells. Tissue Eng Part C Methods. 2010 Feb;16(1):123-32. doi: 10.1089/ten.TEC.2008.0634. PMID: 19397473.

  11. Herrera MB, Bruno S, Buttiglieri S, Tetta C, Gatti S, Deregibus MC, Bussolati B, Camussi G. Isolation and characterization of a stem cell population from adult human liver. Stem Cells. 2006 Dec;24(12):2840-50. doi: 10.1634/stemcells.2006-0114. Epub 2006 Aug 31. PMID: 16945998.

  12. Bruno S, Chiabotto G, Camussi G. Extracellular Vesicles: A Therapeutic Option for Liver Fibrosis. Int J Mol Sci. 2020 Jun 15;21(12):4255. doi: 10.3390/ijms21124255. PMID: 32549355; PMCID: PMC7352992.

Urea Cycle Disorder

  1. Tapparo M, Saccu G, Pasquino C, Fonsato V, Medana C, Schiavo V, Mecarelli E, Maccagno M, Silengo L, Bruno S, Camussi G, Herrera Sanchez MB. In vitro characterization of 3D culture-based differentiation of human liver stem cells. Front Cell Dev Biol. 2024 Feb 8;12:1352013. doi: 10.3389/fcell.2024.1352013. PMID: 38389704; PMCID: PMC10881830.

  2. Herrera Sanchez MB, Previdi S, Bruno S, Fonsato V, Deregibus MC, Kholia S, Petrillo S, Tolosano E, Critelli R, Spada M, Romagnoli R, Salizzoni M, Tetta C, Camussi G. Extracellular vesicles from human liver stem cells restore argininosuccinate synthase deficiency. Stem Cell Res Ther. 2017 Jul 27;8(1):176. doi: 10.1186/s13287-017-0628-9. PMID: 28750687; PMCID: PMC5531104.

  3. Herrera Sanchez MB, Kholia S, Bruno S, Camussi G. Extracellular Vesicles from Human Liver Stem Cells as an Alternative Therapeutic Approach for the Treatment of Urea Cycle Diseases., J Stem Cell Res Dev 2020. DOI: 10.24966/SRDT-2060/100039.

Phase 1 Clinical trial - Administration of Human Liver Stem Cells in infants with inherited Neonatal-onset Hyperammonemia.

Extracellular vesicles & other diseases

Extracellular vesicles - Biomarkers

Essential Reviews

  1. Ceccotti E, Saccu G, Herrera Sanchez MB, Bruno S. Naïve or Engineered Extracellular Vesicles from Different Cell Sources: Therapeutic Tools for Kidney Diseases. Pharmaceutics. 2023 Jun 12;15(6):1715. doi: 10.3390/pharmaceutics15061715. PMID: 37376163; PMCID: PMC10303377.

  2. Bruno S, Chiabotto G, Camussi G. Extracellular Vesicles: A Therapeutic Option for Liver Fibrosis. Int J Mol Sci. 2020 Jun 15;21(12):4255. doi: 10.3390/ijms21124255. PMID: 32549355; PMCID: PMC7352992.

  3. Bruno S, Herrera Sanchez MB, Chiabotto G, Fonsato V, Navarro-Tableros V, Pasquino C, Tapparo M, Camussi G. Human Liver Stem Cells: A Liver-Derived Mesenchymal Stromal Cell-Like Population With Pro-regenerative Properties. Front Cell Dev Biol. 2021 Apr 26;9:644088. doi: 10.3389/fcell.2021.644088. PMID: 33981703; PMCID: PMC8107725.

  4. Chiabotto G, Pasquino C, Camussi G, Bruno S. Molecular Pathways Modulated by Mesenchymal Stromal Cells and Their Extracellular Vesicles in Experimental Models of Liver Fibrosis. Front Cell Dev Biol. 2020 Dec 8;8:594794. doi: 10.3389/fcell.2020.594794. PMID: 33425900; PMCID: PMC7794013.

  5. Tetta C, Deregibus MC, Camussi G. Stem cells and stem cell-derived extracellular vesicles in acute and chronic kidney diseases: mechanisms of repair. Ann Transl Med. 2020 Apr;8(8):570. doi: 10.21037/atm.2020.03.19. PMID: 32775371; PMCID: PMC7347774.

  6. Bruno S, Kholia S, Deregibus MC, Camussi G. The Role of Extracellular Vesicles as Paracrine Effectors in Stem Cell-Based Therapies. Adv Exp Med Biol. 2019;1201:175-193. doi: 10.1007/978-3-030-31206-0_9. PMID: 31898787.

  7. Herrera Sanchez MB, Kholia S, Bruno S, Camussi G. Extracellular Vesicles from Human Liver Stem Cells as an Alternative Therapeutic Approach for the Treatment of Urea Cycle Diseases., J Stem Cell Res Dev 2020. DOI: 10.24966/SRDT-2060/100039.